Monroe counsels a young woman about brain surgery that could save her life, but risks leaving her permanently disabled. He also clashes with a junior surgeon, displaying his bluntness and prickly sense of humor. At home, Monroe’s wife walks out on him as his personal life plunges into turmoil.
When two critically injured teenaged boys are admitted to St. Matthew’s with gunshot wounds, Monroe wrestles with saving their lives as well as learning the truth about how it happened. His troubles don’t stop there: he also must explain the reasons for his imminent divorce to his son.
Monroe feels pressured to operate on a blood clot in an ex-soldier’s brain, though the sharp-witted doctor is certain it will disappear on its own. A little of the ice melts around Bremner as she takes special interest in an elderly heart patient’s chancy operation, and finds herself confiding in Monroe despite all her misgivings.
An epileptic whose brain surgery might “cure” his religious visions causes trouble for Monroe. The doctor also discovers that divorce is a rockier road than expected, but dating is possibly worse. Bremner is livid to find that her involvement with Shepherd has become the subject of hospital gossip, but she has her hands full with two complex new patients.
A member of Monroe’s team collapses with an aneurysm during surgery, forcing him to operate immediately. His son Nick pushes him to try and save his marriage, although Monroe is unsure how to do that. With their romantic involvement common knowledge, Bremner and Shepherd must choose whether to continue their relationship.
A young accident victim’s dangerous surgery forces Monroe to confront a harrowing tragedy in his own past. Meanwhile, the hospital staff faces major shakeupsincluding the possible departure of Shepherdas its trainees learn their assessments. Monroe and his estranged wife talk about their past, while Bremner and Shepherd discuss their future.